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A | (ECNS) -- A university in southwest China is planning to allow students to bring pets to campus, sparking debate over how such a policy could affect campus life and animal management. Kunming City College in Yunnan Province announced the plan through its official WeChat account, with the post quickly attracting 29,000 views on social media. Under the plan, the college will establish pet-friendly dormitories where all roommates agree to keep pets, while a daytime care center will look after animals when students are in class. Most areas of the campus, with the exception of dining halls, will now be open to pets and will be equipped with water stations, fences and cleaning supplies. A dedicated pet health station will also provide free checkups and consultations, maintain health records and will test whether the pets are vaccinated each semester. Cats and dogs will be allowed, along with small animals such as rabbits and hamsters and exotic pets permitted under Chinese law. However, dog breeds banned in the city, as well as animals considered aggressive or potentially harmful to human health, will not be permitted. The proposal has received support from students. Those who normally spend months away from their pets would be able to keep them nearby, helping ease homesickness while also providing the animals with more consistent care. However, the plan has also raised concerns, particularly over allergies, fear of animals and the challenges of keeping pets in shared dormitories, including noise, waste and the risk of bites or fights. In response, the college said the proposal was based on years of experience rather than a spur-of-the-moment decision. The university has long provided shelter for stray animals on campus and this year established a school of pet science and technology, offering programs in areas including pet medicine, care and training. Before the policy takes effect, the university will conduct further research and take individual circumstances into consideration, with detailed rules expected to be introduced later this year. The move comes as more schools in China experiment with pet-friendly policies. In 2023, Nanning No. 2 High School in Guangxi Zhuang Autonomous Region allowed students to keep one pet per class as part of a student-led initiative aimed at easing academic pressure and helping students become more responsible. At least eight Chinese universities have launched pilot programs allowing students to bring pets to campus, with most targeting students entering university in 2026 and giving priority to those studying pet-related majors. (By Helen Mo & intern Liu Shuangjing)
。 由麦凯尔维工程学院机械工程和材料科学的Lilyan & E. Lisle Hughes教授Srikanth Singamaneni和Singamaneni实验室的前博士后Anushree Seth领导的研究人员开发了FluoroDOT测定法。该研究最近发表在《细胞报告方法》上。

B | 这种高度敏感的检测方法能够在大约30分钟内看到并测量单个细胞分泌的蛋白质。

C | 树突状细胞在不同时间点分泌蛋白1(TNFa,红色显示)和蛋白2(IL-6,黄色显示)的FluoroDOT检测图像(从左到右。未受刺激、受刺激30分钟、1小时、2小时和3小时)。

D | 细胞的细胞核以蓝色显示。白色箭头突出显示了只分泌一种蛋白质或两种蛋白质的不同数量和不同时间点的细胞。

E | 图像: Srikanth Singamaneni/华盛顿大学与来自其他大学和华盛顿大学医学院的科学家一起发现FluoroDOT检测法用途广泛,价格低廉,可适应任何实验室环境,并且有可能比目前常用的检测法更全面地了解这些蛋白质。生物医学研究人员通过分泌蛋白来了解细胞间通讯、细胞信号传导、激活和炎症等方面的信息,但目前的方法在敏感性方面受到限制,而且可能需要24小时的繁琐处理流程。质子-荧光是Singamaneni实验室创造的一种质子增强的纳米标签,比传统的荧光标签亮16000倍,信噪比超过30倍,这是FluoroDOT检测法与其他检测法的区别所在。Singamaneni说:"质子-荧光剂是由金属纳米粒子组成的,它作为天线拉入光线并增强分子荧光团的荧光发射,从而使它成为一种超亮的纳米粒子。"这种质子-荧光的超亮发射使用户能够看到极少量的分泌蛋白,这是他们在现有测定法中无法做到的,加上利用定制的算法,用每个簇或斑点的颗粒数量或点状图案,实现以数字方式测量高分辨率信号。此外,它不需要特殊设备。Singamaneni和他的合作者于2020年在《自然-生物医学工程》杂志上首次发表了他们的等离子体氟化物工作。这项正在申请专利的质子荧光技术由圣路易斯华盛顿大学技术管理办公室授权给Auragent生物科学有限公司。"使用一个简单的荧光显微镜,我们能够同时对一个细胞以及它周围分泌的蛋白质的空间分布进行成像,"Seth说,他作为Singamaneni实验室的博士后学者从事这个项目,并作为Auragent生物科学公司的首席科学家(细胞应用)继续从事这项工作。

F | "我们看到不同细胞类型的有趣分泌模式。这种检测方法还能同时观察来自单个细胞的两种类型的蛋白质。当多个细胞受到相同的刺激时,我们可以将同时分泌两种蛋白质的细胞与只分泌一种蛋白质或根本不分泌的细胞区分开来。"为了验证这项技术,该团队使用了从人类和小鼠细胞中分泌的蛋白质,包括感染了结核分枝杆菌的免疫细胞。

G | 合作者和共同作者之一,医学博士Jennifer A. Philips,医学和分子微生物学系的Theodore和Bertha Bryan教授,以及医学院传染病科的共同主任,已经在她的实验室中使用了FluoroDOT测定。Philips举例说:"当结核分枝杆菌感染免疫细胞时,这些细胞通过分泌重要的免疫蛋白(称为细胞因子)做出反应。

H | 但不是所有的细胞都以同样的方式对感染做出反应。

I | FluoroDOT测定使我们能够看到群体中的单个细胞如何对感染做出反应--看到哪些细胞正在分泌以及朝哪个方向分泌。这在旧技术中是不可能的。
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